Hello everything has happened so fast my routine mammo came back abnormal then had Disgnostic mammo and ultrasound , showed 2 masses . Had biopsies done and in one mass it showed malignant invasive and in-situ cancer (lI). Breast Cancer Analysis – Immunohistochemistry
Estrogen Receptor – Positive – Moderate staining in 100% of tumor cell nuclei
Estrogen Receptor – Allred Score 7
Progesterone Receptor – Positive – Strong staining in 100% of tumor cell nuclei
Progesterone Receptor – Allred Score 8
HER2 - Equivocal (2+)
Breast cancers with HER2 IHC score 1+ or HER2 IHC score 2+ and a negative ISH results are eligible for clinically appropriate HER2-targeted therapy and may be reported as “HER2 low”.
I’m not sure what this means? Can anyone explain, I know they r doing more smears I meet with oncology on Monday and Surgeon the following week. My OBGYN called me and told me I needed to have my IUD removed and stop taking estrogen (which I stopped already )
Any advise is appreciated
So sorry you are going through this and i wish i could help with all the jargon and terms used. I just wanted to offer support. Ask all these questions when you meet with your oncologists. Im sure they will go through it all. It’s hard to take it all in so write things down if you need to. I wish i could be more help. But sending lots of love. Xxx
We know there can be a lot of information and questions around a diagnosis, and it can be confusing to know what matters. If you wished to chat things through with our team of breast care nurses, please remember we are right here.
Hi @lincoln24 in essence this boils down to your tumours being Er+ 7/8 Pr+ 8/8 HER2-. In other words you have the cancer that 70-80% of people, myself included, have had. This means that you are on a well-worn path to fully understood and very effective treatment. I was ER+ 8/8 Pr+ 6/8 HER2- and, depending on the size and grade of the tumours once they’ve come out and been analysed, it should mean that you’ll find endocrine treatment, if you choose to take it, very effective. The Allred scores are worth knowing, all the other gobbledygook, not important for us to know. The other issue about having a DCIS (non invasive tumour) mixed in, that’s also very common. I had it myself. They whip it out with all the other stuff in surgery. As I always say, ask your question before signing any consent forms so that you can be confident that you know what it all means. Some people don’t want to know which is a legitimate response but if you do, ask away! Good luck!