Palbociclib blood results

Living with secondary breast cancer Treatments and medical issues
1

Hello Ladies,
I was wondering if anyone else has had a similar experience to me on the palbociclib/letrozole regime. Since starting the drug in Jan 2022 my haemoglobin levels have been dropping. The latest result is 89. Also my platelet count has dropped to 94.  My dose was reduced from 125 to 100mg last month due to low neutrophils (two months in a row with low neutrophils). I’ve just received the latest blood results after one cycle on the reduced dose and to my dismay the neutrophils are 0.6 and I will have to delay treatment again by a week. Do you think it just takes the body a while to adjust to the new dose or will I have to reduce the dose again? I’m really concerned that, although the drug combo is proving effective in treating the cancer, my bloods are struggling. 

Best wishes to you all,

Jo

2

Hi Jo

The same thing happened to me

I was low for the first few sessions and then they lowered the dose, which I was really concerned about but the doctor said it’s better to be regular with the treatment than have the higher dose. My first one with the lower dose was still low and delayed but then after that I’ve been ok and at 1.1 ish for my neutrophils. My oncologist said that the first month with the lower dose the body is still adjusting, so hopefully your next one will be fine like mine has been. I also found that when I adjusted to the lower dose I’ve been a lot less tired so will keep everything crossed for you x