Hi All
Im looking for any info on PARP inhibitiors as a treatment for tnbc. I was dx in jan and had a mx and chemo but Ive had a recurrence (skin mets) immediately after completing chemo (Fec-tax). Ive just had a massive op to remove the affected skin and Im having rads and probably more chemo- will know more when I have my follow up appt on Weds.
Just wondering if any of you have tried PARPs and how effective they were? They seem quite widely used in the US and results have been very good but things seem to be in the very early trial stages here…
Any info would be great.
Thanks
Tina x
Duplicate post? Have already replied on your other thread!
Hi gingerbud, I found this on Breast Cancer.org web site
17 June 2010
Andrew Seidman, M.D.: While we still await the data from a large randomized Phase III trial evaluating BSI-201, there were several smaller studies reported at this year’s ASCO meeting. One study involved the oral PARP inhibitor olaparib, which was administered with weekly Taxol (chemical name: paclitaxel) chemotherapy for triple-negative metastatic breast cancer. (Abstract number 1018 at ASCO.) Another study examined yet another PARP inhibitor, veliparib, in combination with a chemotherapy agent called Temodar (chemical name: temozolomide). In this trial, significant responses were seen in patients with metastatic breast cancer who carried BRCA mutations. Still, to date there are no commercially available PARP inhibitors, and their ultimate role depends upon the awaited results of large randomized trials.
best wishes Mel xx
Thanks for that Mel. My husband and I have read some really promising stuff online- particularly results from the US. I am going to ask my team about trials on Wednesday when I have my follow up appt. My genetic test results are not back yet and should be quite some time- I may have the tests done again privately to speed up the process if I am only able to participate in trials with a positive result.
Anyone been involved in the trials?
Thanks
Tina xx
As I said on the previous thread-it is being used in the U.S differently to what is happening here, and Mel appears to have given you info from America. It may be possible for you to travel abroad for this, but think that would be a drastic step to take.
Hi I didn’t realise that it would be different in the US,why is this?.Does every country have to do their own trials to come to the same conclusions.That seems a bit silly to me,or have I got it all wrong. (probably knowing me lol).
Best wishes Mel xx
Absolutely. It’s a good thing, in many ways. The U.S are further advanced than we are with PARP-and are using it in a different way-with a fair degree of success. We are pursuing different avenues, also reasonably succesfully-so many more people stand to benefit.There are many differences bewteen treatment protocols here and in other countries-think we’re a long way away from having a universal system. Interestingly, the researchers here did consider extending the trial to TN but decided against it-opting instead to open it to prostate cancer sufferers.
So the trials in the US,if they were found to benefit triple negative and the treatment made available in the US would it be available here too or do we have to do our own trials.Oh god I sound soo dim but am really confused about it.
Mel xx
It is confusing isn’t it mel! Me+ my hubby have found some promising results in the US with triple negs so it seems bizarre that in this country they are doing their own thing despite the evidence! I am going to discuss it all with my team tomorrow. You can actually buy parps online from china- I wouldn’t risk such a d.I.y. approach obviously although it’s tempting when you are desperate…
Tina xx
Hi Tina
Do let us know how you get on discussing it with your team. Will be interested to hear what they say.
Thanks Anne x x
Will do thanks Anne. Meeting my onc on Wednesday and Im going to push him about Parps as there seems to be alot of promising stuff out there about them.
Ive done a bit of research and Ive found a company that do BRCA analysis privately in a turnaround time of 3wks. It seems that you can only access trials if brca1 or 2- I would hate to find out down the line (when its too late for parps) that I do carry a mutation so I think I’ll pay the £1500. A sample is currently being tested as part of the familial bc study- its looking at brca3 but rules out brca1 and2 first. Ive been told it’ll probably be another 6mths before I hear from them so think I’m going to pay.
Awaiting liver mri scan results any day now-probably tomorrow as Im in clinic. Im worried sick…
speak soon
Tina x