Post zolodex but still taking tamoxifen

Hiya my wife has stopped taking zolodex but still on tamoxifen she had her last injection at the end of may due to her not being able to cope with the side effects of it

How long does it take for the zolodex to be completely out of her system and for her ovaries starting to work again 

She still seems like she is struggling even going to work she said she is struggling with she says her mind and memory just ain’t the same anymore 

 Thank you kind regards rick

Hi Rick1987  

Thank you for your post.   

It sounds like your wife is having a difficult time.    

It’s understandable that you want to know how long it will take before zoladex  is completely out of her system.    

The effect of zoladex is usually temporary and after finishing the treatment, the ovaries will usually start to produce oestrogen again. Periods can start again, and this is normally within three to twelve months after finishing treatment. However, if a woman is approaching the age of natural menopause, her ovaries may not start working again. As she is on tamoxifen this may also impact on this.  

You don’t mention which side effects your wife is having, it may be helpful for her to contact her breast care nurse, treatment team or GP to talk through how she is feeling, they may be able to offer advice on how long these may take to resolve and offer further support.  You mention that your wife is struggling going to work she may find our information about working after breast cancer treatment helpful.   

After breast cancer treatment many people are surprised at how emotional they feel when their treatment finishes and find they do struggle. For many people, it’s not always ‘back to normal’ when they finish hospital treatment for primary breast cancer. Adapting to life after treatment can be difficult and often the need for information and support continues.   

Your wife may be interested in our resources that are particularly for those who have come to the end of their main hospital treatment. These are known as our Moving Forward services and include our  Moving Forward booklet and Moving Forward courses.   

She may also find it helpful talking to someone who has had a similar experience can often be helpful. Our Someone Like Me service can match you with a trained volunteer who’s had a similar experience to you.  You can be in touch with your volunteer by phone or email for them to answer your questions, offer support or simply listen. 

You can ring the Someone Like Me team on 0114 263 6490 or email them at, so they can then match you to your volunteer.   

We are currently evaluating this service and would appreciate your feedback. Please click here to the survey. It should take approximately 10 minutes to complete.   

Do call our helpline if you would like to talk this through or have any further questions. The helpline team have time to listen to your concerns, talk things through and signpost you to more support and information. Your call will be confidential, and the number is free from UK landlines and all mobile networks. The number is 0808 800 6000, (Relay UK - prefix 18001). 

If you would prefer one of our nurses to call you. To do this, please complete this form ticking the box agreeing to a call back.   

Our usual opening hours are Monday to Friday 9am - 4pm and 9am - 1pm on Saturday.   

Out of hours you can leave a message and we will call you back when we next open.  

Best wishes  


Breast Care Nurse   

Please read the Ask Our Nurses disclaimer  Full details on how we collect and use your data can be found in our Privacy Policy    

This thread will now be closed from further replies. If you have any additional questions or would like to provide feedback, please start a new thread.