Noted this drug is now licenced for stage 2 and 3 HR+ HER- patients at “high risk of recurrence”. How is this defined- I believed all HR+ cancers had chance of recurrence?
1 Like
I don’t know, but I’ve been wondering if this is something I could ask to go on. I was put on biphosphonates to reduce risk of recurrence but they caused eye problems in me. This might be a good alternative. I’m sure a nurse will tell is soon, but i think the cancer is high risk if it is larger in size, multi-focal or multi centric, in the nodes, grade 2 or 3. There may be genetic factors too. I’ll ask when i see my oncologist in August.
I wondered that too - I was multifocal with LVI and 2/3 positive nodes.
The press release from Novartis sums it up well. Basically same criteria as the Natalee clinical trial. I have copied it below:
The recommendation is based on results from the Phase III NATALEE trial, which included 5,101 pre-/postmenopausal women and men with HR+/HER2- breast cancer with any lymph node involvement (excluding microscopic nodal involvement), or if no nodal involvement either tumour size >5 cm, or tumour size 2-5 cm with either grade 2 (and high genomic risk or Ki67 ≥20%) or grade 3
Hope that helps
All the best.
1 Like
Thank you. I had ki67 of 30, hr +, 4 tumours of 19, 18, 9 and 7mm, plus 3 lymph nodes, all idc grade 2. I will ask about this at next appointment.
1 Like
Hi jooliepie30,
Thanks for your post.
NICE has now approved the use of ribociclib with an aromatase inhibitor for the adjuvant treatment of HR-positive, HER2-negative early breast cancer at high risk of recurrence.
Risk of a breast cancer recurrence is determined by many factors and this varies for each individual. You may find it helpful to speak to your breast care nurse (if you have one) or treatment team about your individual risk. They can advise if this treatment would be appropriate for you.
We offer a range of free supportive services for anyone who has had a diagnosis of breast cancer which you may be interested in. They include face to face and online courses and events.
Do call our helpline if you would like to talk this through or have any further questions. The helpline team have time to listen, talk things through and signpost you to additional support and information if necessary. Your call will be confidential, and the number is free from UK landlines and all mobile networks.
The number is 0808 800 6000. If you have hearing or speech difficulties prefix our number with 18001 and the call will go through Relay UK. Our helpline has access to telephone interpreters if language translation is required.
If you would prefer one of our nurses to call you. Please complete this form ticking the box agreeing to a call back.
Our usual opening hours are Monday to Friday 9am - 4pm and 9am -1pm on Saturday.
Out of hours you can leave a message and we will call you back when we next open.
We’re continually evaluating this service. If you want to provide feedback, please click the link to complete the survey . It should take approximately 10 minutes.
Best wishes
Sonia
Breast Care Nurse
Please read the disclaimer Full details on how we collect and use your data can be found in our Privacy Policy
As we are unable to monitor for further replies, this thread will now be closed. If you have any additional questions or would like to provide feedback, please start a new thread, call our helpline, email us or request a call back.