Ribociclib Letrozole timing

I have just restarted taking a lower dose of Ribociclib and 2.5mg Letrozole after a break to help my liver recover. It seems advice is to take both together in the morning. Why is this? Can they be taken at 6pm ish to minimise side effects when awake?

I needed my Ribociclib dose reduced twice, now on 200mg a day. When I was taking just Letrozole for 7 years after my primary, I always took it at bed time to minimise side effects and I think it did. When I started with Ribociclib plus Letrozole 18 months ago I asked if it was OK to take them at bedtime and was told it was OK so that’s what I do. Best wishes to you.

Hi luludaisy42,

Thanks for posting.

It sounds like a difficult time for you managing your side effects.

Some medicines are important to take at a set time of day to make sure they work effectively. It’s recommended that ribociclib is taken in the morning including from the drug company that produce it Its not particularly clear why this is.

It is also recommended you take it at around the same time every day so that there is an even level of it in your system.

As @AnnieSue suggests, changing the time of day may help with some of your side effects. But it is important to check with your treatment team to make sure they are happy for you to take it at a different time of day.

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