Hello,
I was diagnosed with bone Mets in August 2020 and am about to start ribociclib. I am also on letrozole, which I have been taking in the morning in the vain hope I’d avoid the bad night sweats. I haven’t avoided night sweats!!!
Do any of you notice any difference in side effects for either of these medications depending on what time of day you take them?
Hi
I was I initially advised to take Ribociclib in the morning (just over a year ago) but now the advice is to take it at the same time each day - I think a few hours either way is ok, as long as it is roughly the same time each day, so I take it in the evening now as I can feel a bit out of it s few hours after taking it, and obviously this is easier when I’m asleep rather than at work mid-morning.
all the best, Kinden xx
Hi,
Ive been taking ribociclib for over a year now and although I’ve had a dose reduction it’s working really well and recently great scan results. I’ve always taken it in the morning with breakfast as it’s the best time for me to remember at the same time each day which means that the levels of drug remains more constant in the body. I have to take it with food or I feel nauseated but this has improved with time… and drink lots of water which really helps too.
All very individual I’m sure with timing. Good luck 
x
I was I at first encouraged to take Ribociclib toward the beginning of the day (a little more than a year prior) yet now the counsel is to take it simultaneously every day - I think a couple of hours whichever way is alright, as long as it is generally a similar time every day, so I take it at night now as I can get a handle on a touch of it s few hours subsequent to taking it, and clearly this is simpler when I’m sleeping instead of at work early in the day.
I’m just about to start taking Ribociclib and am quite worried about side effects especially as it is said to lower immunity. How does it effect you
Please try not to worry and see how you actually get on with it. I’ve been on palbociclib, which is very similar, since December 2020. My neutrophils are always low but I’m very rarely ill and I’ve got 2 young children and I travel a lot for work.
Let us know how you get one once you’ve started. It took me a few weeks to adjust to it. Some people do have to lower their dose so please don’t be concerned if that happens to you.x
Thanks for replying. Your message is quite reassuring. I’ve been on it a week now and getting some stomach cramps and fatigue but I’m hopeful, from what you say, this might settle down. X
I felt like I was pregnant when I first started, but after about 6 weeks that disappeared. I do get fatigued, but I try and manage that as we as I can.