Soreness after radiotherapy

I had radiotherapy for 2 weeks ending 6 April 2022 and am on letrozole and ad-cal tablets for 5 years. Unfortunately I had a bone density scan February 2023 which showed I have osteoporosis in spine and hips and Doctor thinks osteoporosis was made worse by letrozole but letrozole would not have caused it - I do not know if this is correct. I also have soreness in my breast and it seems dense, if correct word, or bit firmer than the other breast - would this be the after effects of radiotherapy after all this time?

Hello Ceinwen

Thanks for posting.

Bone density loss is a natural part of aging with women being more at risk than men. This may be why your doctor thinks it wasn’t caused by the letrozole, but that the letrozole did contribute to it because bone density loss is a side effect of this medication.

It’s not clear if you had a bone density scan (DEXA) before you started on the letrozole to compare your recent scan to.

Some side effects of radiotherapy such as discomfort and changes to the texture of the breast can develop months or years after radiotherapy treatment ends. However, as you’ve noticed changes in your breast it’s important to let your team know of these or any new or persistent symptoms you develop. Your team will also be able to explain if you need any further treatment to protect your bones.

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Best wishes


Breast Care Nurse

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