Just sharing some background before I ask the questions I have about (Selective estrogen receptor modulators = SERMs):
Cancer Profile: Grade 2 IDC, ER8, PR8, 1 positive lymph (out of 25), LVI, PI.
I had a single MX & Axillary Dissection surgery followed by 5 fractions of 26G RT as my primary treatment. No Chemo due to ODX score.
The 5-10 year Endocrine treatment regime I’m on is Letrozole. I have been on it for 8 months and am doing some reading/research on whether to continue with it, or change to a SERM instead. The reason for this is primarily due to concerns around bone health (my baseline DEXA scan highlighted osteopenia) as I already have back and neck pain, secondary concerns around other risks to overall health with oestrogen depletion & thirdly short term joint pain/fatigue side effects of letrozole (AI).
I have spoken to both my GP & Oncologist about what options are available to manage my bone health aside from weight bearing exercises. Both have mentioned Vitamin D & Calcium. I have been taking vitamin D for years so nothing new to change there, and have sufficient calcium in my diet according to a recent calculation I did via an online calculator. I raised the question about Bisphosphonates, it’s not one I was offered as part of oncology treatment as my cancer risk recurrence profile (low ODX score, no chemo) isn’t high enough, I fall under the intermediate risk profile.
My oncologist has previously mentioned Tamoxifen as an alternative, but it also comes with it’s own risk factors (The primary ones I have noted is EC/UC or Endometrial / Uterine Cancer, Blood clots).
I am due to see a Rheumatologist to discuss what would be recommended given above factors. The main bone hardening treatment type I was aware of before was Bishposphonates, but since researching online I’ve recently discovered that there is another drug called Raloxifen (Evista) which is a “SERM” (Selective estrogen receptor modulator) used to reduce the risk of spinal fractures in women after the menopause; Tamoxifen is also a SERM. And upon reading about Raloxifen I see it is also a possible drug for BC recurrence risk management, which does not come with the Uterine Cancer risk that is associated with Tamoxifen. So it appears that Raloxifen could have a dual function for someone who has had BC & is post-menopausal. It’s not a drug that my Oncologist has ever mentioned, and neither has my GP, when discussing bone strength.
So before I see the rheumatologist I’d like to have as much information on hand with me to enable an informative discussion on viable options for managing both bone health, while also managing my breast cancer recurrence risk.
I would like to hear from anyone who has information about this treatment option, or even experience taking it. If anyone else has had a similar discussion with their Oncologist/treatment team, any information/findings you have would be much appreciated.