Hi ladies


Has anyone been tested for the TP53 gene? I have have been cleared of having the BRCA 1 & BRCA2 and they are now testing for TP53.


I had breast cancer last year, bi lateral mastectomy because of family history…just wondered if anyone could give me any info on this



wishing you all well xxxx



I haven’t been tested for anything, but was diagnosed with a phylloid tumour which is a very rare type of breast cancer that affects 0.03% of women, on March 27th 2015. From my own research (consultant at Guy’s cannot waste time with rare tumours and haven’t met up with my original surgeon even once, next surgery on April 29) TP53 is associated with phyllodes (not sure about other types of Breast Cancer, phyllodes is more of conjuctive/stromal/sarcoma type of thing).


Not sure this helps but hey it’s a response! :manhappy:


any other weirdo out there with phyllodes can you get in touch? would be fab. 





I think TP53 has a role in phyllodes tumours which is a rare form of breast cancer that affects 0.03% of the female population.

hi ladies
im being tested for tp53 gene. Its freaking the hell out of me now.
its based on my nans diagnosis.( my mums mum) she had bowel cancer then 5 years later a brain tumor.
My mum and sisters have not had or got cancer neither has my uncle or his 2 daughters. Just me. Im hoping its not a genetic fault really for the sake of my kids to.
how do you deal with this im strugiling at the moment.
i want to know so we can protect ourselfs but i dont want to at the same time.
How are you ladies dealing with it
joanne x

Hi Erica
i only had my testing done on tuesday. She ruled out the BRCA gene as my history had no concern for her. No bc or ovarian in the family. She then bought up the TP53 gene which id not heard of so panic there already.
she sugested it may be due to the fact my nan had 2 cancers one was a brain tumor which she said is linked to bc. no one else in my family on my mums side has had or got cancer just me. My mum is 66 i am the eldest child of 3 girls.

Im due surgery 9th june just a lumpectomy but if results come back positive it will be dmx And recon.
i think my surgeon is going to try and push for the reults sooner as he only wants to do one surgery if nessacary. If not he said he wants to deal with the cancer in hand and hold off the radiotherapy.

Such alot to get my head around again.
Thanks for getting intouch Erica it certainly does help with people going through the same storm.
joanne x

My hospital is in south london, kings college. They give rads to everyone who has a lumpectomy but they can hold off for a while if need be.
i got refered for genetics by my onc as im young and the type of cancer i have. im grade 2 stage 2 Her2positive.
i hate the waiting and the thought it could be a faulty gene. Im scared for the kids to.
I hope its just my bad luck and once i have my lump removed i just want it all to be over but i feel if its a faulty gene it will be far from over
joanne x