Triple Negative BC and HRT


I’m trying to find information about TNBC and HRT. General advice is HRT is not recommended for patients that have had BC but there doesn’t seem to be much evidence about the whether this risk is the same for those that had TNBC. 
I’m wondering who I should speak to, my GP or try and speak with my oncologist (not easy to do). 
Aside from HRT, what are the options for brain fog, protecting my bones and hot flushes?


Hi Emma_B 

Thank you for posting and asking about the risks of HRT for people with triple negative breast cancer (TNBC).  

As you say, HRT is not usually recommended for anyone with a history of breast cancer and this is the same for people with TNBC. 

This is because research has shown that hormones such as progesterone and oestrogen can cause breast cancer cells to grow and potentially increase the risk of breast cancer recurrence. Although TNBC cells don’t respond to hormones in the same way as hormone positive cancers, there is not enough current research to suggest that the risk is less for people with triple negative breast cancer, and the data from trials in inconclusive. Therefore, it is usually advised that people with TNBC also avoid HRT. 

You ask if there are other options for managing menopausal symptoms such as brain fog, bone health and hot flushes. Information on the links might be if interest and you may find it helpful to watch our YouTube video

Hot flushes are the most reported menopausal symptom due to breast cancer treatment and many women contact us describing the difficulties they are experiencing with them. The frequency and severity of them vary from person to person. For most women they will fade over time and become less severe, but for some they may continue to experience hot flushes which can really affect their quality of life. 

We know that there are different things that help with hot flushes.  Complementary therapies may also help to improve some menopausal symptoms and your breast care nurse will be able to advise you on whether there are any local services that you can be referred to. 

It is important to let your treatment team know if you are experiencing side effects from treatment. If you are finding it difficult to contact your oncologist, it may help to speak with your breast care nurse to discuss possible options for managing hot flushes. Your GP may also be able to help. You may want to ask about a referral to specialist menopause clinic where you can get further advice and information about coping with menopausal symptoms. 

We offer a range of free supportive services for anyone who has had a diagnosis of breast cancer which you may be interested in. They include face to face and online courses and events.  

For more details about all of these services, please see the information on the link, or call our free helpline. 

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Best wishes 


Breast Care Nurse 

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