Violent cramp in toes and lower leg

Hello. From time to time i have violent cramp in my toes. They literally twist around each other, and in my lower legs, on the outside not in the calf muscles. This is often at night, is agonising and doesn’t go away by moving about. Taking high doses of magnesium has helped but not stopped it altogether. Could this msybe be a side effect of Tamoxifen? I have been on it for over a ye
Ar and never had this problem before. Thank yiu for any advice.

Hi Ive got the same, been on letrozole for 3 years, always had high colestrol but again managed it without medication. Letrozole can raise colestrol doc put me on statins last year. I noticed cramps at the gym to begin with put it down to my age 70 +. Then the cramps got worse like you unable to sleep. Letrozole and statins affects people diffrently, read up on it, stopped taking statins and the cramps began to subside. Informed the doctor awaiting a review. Are you taking other medication that could interact with Tamoxifen.

Hi Mary. Thanks for responding. That’s interesting that you experienced something similar on letrosol and statins. I don’t take any other medication. I’m glad to hear your cramps have subsided. I will check with my GP. My gynocologist didn’t have any advice.

Hi deegee

It sounds as though the cramps you describe are really bothersome, particularly at night.

It’s difficult to say if its anything to do with the tamoxifen you are taking but some people have reported leg cramps at night There can be many reasons for leg cramps as indicated by @Mary_1 but sometimes the reason may be unknown so it’s best to talk to your GP as you plan to do.

If you are still under follow up at the hospital, it would be a good idea to also check this out with your treatment team as they may suggest a short break from the tamoxifen to see if your symptoms improve. If you are no longer under follow up, your GP may contact your treatment team about your symptoms or refer you back to see them about this.

It may also be helpful to read our information about things to try when you have trouble sleeping.

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